202 results found for lindau-nobel

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00:33:00

Molecules Against Cancer or for Long-Term Memory Storage

by Roger Tsien
Molecules Against Cancer or for Long-Term Memory Storage
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1797 views
Rating:

For cancer diagnosis and therapy, we are developing activatable cell-penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell-penetrating peptides whose cellular ....

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00:36:00

A Personal View of the History of Nuclear Magnetic Resonance in Biology and Medicine

by Kurt Wurthrich
A Personal View of the History of Nuclear Magnetic Resonance in Biology and Medicine
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1992 views
Rating:

In 1952, Felix Bloch and Edward Purcell were awarded the Nobel Prize in Physics for the description of the phenomenon of nuclear magnetic resonance (NMR). Over the years, NMR has been used in a wide range of fundamental studies in physics, and in the....

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00:32:00

Aquaporin Water Channels _ From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels _ From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 3701 views
Rating:

Aquaporin (AQP) water channel proteins enable high water permeability in certain biological membranes. Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known. Expres....

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00:34:00

Synthetic Biology for Genetic Engineering in the 21st Century

by Hamilton Smith
Synthetic Biology for Genetic Engineering in the 21st Century
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1544 views
Rating:

Synthetic biologists seek to design, build, and test novel biological systems. We have chemically synthesized a bacterial genome (Mycoplsama mycoides, 1078Kb) and brought it to life by transplantation into the cytoplasm of a related species. We are....

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00:39:00

You can see a lot by observing: Optical Microscopy 2.0

by Steve Chu
You can see a lot by observing: Optical Microscopy 2.0
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1570 views
Rating:

Biological research and medicine were transformed by the invention and improvement of the optical microscope. Since the early 1990s, there has been another revolution in optical imaging, and manipulation of individual biological molecules and bio-mo....

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00:32:00

The Revolution of Personalized Medicine: Are We Going to Cure All Diseases and at What Price?

by Aaron Ciechanover
The Revolution of Personalized Medicine: Are We Going to Cure All Diseases and at What Price?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1657 views
Rating:

Many important drugs such as penicillin, aspirin, or digitalis, were discovered by serendipity - some by curious researchers who accidentally noted a "strange" phenomenon, and some by isolation of active ingredients form plants known for centuries to....

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00:28:00

From the Structure of the Ribosome to New Antibiotics

by Thomas Steitz
From the Structure of the Ribosome to New Antibiotics
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1653 views
Rating:

Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanisms of action of a....

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00:31:00

Infections Linked to Human Cancers: Mechanisms and Synergisms

by Harald Zur Hausen
Infections Linked to Human Cancers: Mechanisms and Synergisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1414 views
Rating:

Slightly more than 20% of the global cancer incidence is presently being linked to viral, bacterial, or parasitic infections. The mechanisms by which these agents mediate malignant transformation differ substantially. Some contribute directly, freq....

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00:32:00

Why Do We Not Have a Vaccine Against HIV or Tuberculosis?

by Rolf Zinkernagel
Why Do We Not Have a Vaccine Against HIV or Tuberculosis?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1505 views
Rating:

Analysis of the immune system is fascinating and progressing rapidly. As a field of medical enquiry, it has however, drifted and turned purely academic. This is because interest and appreciation of protective immunity in infectious disease medicine....

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00:32:00

On The Road Toward an HIV Cure

by Franoise BarrŽ-Sinoussi
On The Road Toward an HIV Cure
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1334 views
Rating:

Since the first cases of AIDS in 1981 and the identification of its etiological agent in 1983, much progress has been made in both the development of tools to prevent and treat HIV infection and the access to these tools. In particular, the wide arr....

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00:30:00

Inheritance from Teratomas

by Martin Evans
Inheritance from Teratomas
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1385 views
Rating:

The techniques and concepts that have resulted in the identification and isolation of embryonic stem cells have come from studies with mouse teratocarcinomas. Embryonic stem cells isolated from normal mouse embryos may be grown in tissue culture and....

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00:31:00

Forging a Genetic Paradigm for Cancer

by Michael Bishop
Forging a Genetic Paradigm for Cancer
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1609 views
Rating:

It is now axiomatic that, no matter what its causes, cancer ultimately arises from the malfunction of genes. A number of clues prefigured this paradigm: the persistence of the malignant phenotype through countless cell divisions; the mutagenicity of....

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00:32:00

Man vs. Helicobacter _ The past 50,000 years and the next 50

by Barry Marshall
Man vs. Helicobacter _ The past 50,000 years and the next 50
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1794 views
Rating:

The epidemiology of Helicobacter pylori continues to be an area of discovery and controversy in the 21st century. The transmission of this bacterium from mother to child allows Helicobacter DNA to mimic the evolution of maternal mitochondria DNA. B....

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00:31:00

Deciphering Immunity by Making It Fail

by Bruce Beutler
Deciphering Immunity by Making It Fail
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1752 views
Rating:

Infectious microbes collectively represent the strongest selective pressure operating on our species, and over hundreds of millions of years, drove the evolution of the sophisticated immune system we have today. While the general outlines of immune ....

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00:32:00

Innate Immunity: From Flies to Humans

by Jules Hoffmann
Innate Immunity: From Flies to Humans
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1764 views
Rating:

Flies challenged with bacteria or fungi rapidly transcribe a battery of genes encoding potent antimicrobial peptides which oppose the invading microorganisms. Genetic analysis has identified two signaling cascades which control their expression: (1)....

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00:31:00

Multiscale Simulations of the Functions of Biological Molecules

by Arieh Warshel
Multiscale Simulations of the Functions of Biological Molecules
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 2925 views
Rating:

Despite enormous advances in structural studies of biological systems we are frequently left without a clear structure-function correlation and cannot fully describe how different systems actually work. This introduces a major challenge for computer....

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00:31:00

Genes and Proteins that Control Secretion and Autophagy

by Randy Schekman
Genes and Proteins that Control Secretion and Autophagy
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 3645 views
Rating:

The broad outlines of the secretory pathway were established by pioneering EM and cell fractionation experiments conducted by George Palade in the 1960s. Beginning in the mid 1970s and early 80s, my laboratory isolated a series of conditionally leth....

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00:37:00

Cosmic Rays: the Most Energetic Particles in the Universe

by James Cronin
Cosmic Rays: the Most Energetic Particles in the Universe
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1400 views
Rating:

Astrophysical objects are able to accelerate atomic nuclei to energies 10^7 times more than man made accelerators such as LHC. _Particles arrive at earth from space with energies as great as 50 joules, a macroscopic energy in a microscopic particle.....

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00:39:00

The World of Spintronics: Electrons, Spins, Computers and Telephones

by Albert Fert
The World of Spintronics: Electrons, Spins, Computers and Telephones
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1289 views
Rating:

Spintronics is a new field of research which exploits the influence of the electron spin on electronic transport. It is well known for the giant magnetoresistance of the magnetic multilayers and its application to increase the capacity of the hard d....

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00:32:00

The Big Challenges

by Gerardus t'Hooft
The Big Challenges
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1284 views
Rating:

During the entire 20th century, physical sciences have advanced to such a degree that we can extrapolate how they can be applied, even in a fairly distant future.  Even if we leave open the (likely) possibility of spectacular new discoveries and inv....

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00:34:00

Frontiers of Physics

by David Gross
Frontiers of Physics
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1696 views
Rating:

David discusses a few of the questions facing fundamental physics that might be answered before the 100th Lindau meeting in 2050.

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00:32:00

The Looming World Shortage of Helium

by Robert Richardson
The Looming World Shortage of Helium
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1244 views
Rating:

The worldÍs supply of Helium gas comes primarily from alpha decay in rocks. The most abundant supply is in the American Southwest where it is trapped with methane is natural gas wells. That supply is estimated to last a mere 25 years. It took 4.7 bi....

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00:28:00

The History of the Universe, from the Beginning to the Ultimate End

by John Mather
The History of the Universe, from the Beginning to the Ultimate End
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1302 views
Rating:

John summarizes the history of the universe, from the Big Bang through the formation of galaxies and the Solar System, and the history of the Earth and some of the special factors enabling the formation of life.  Our future will be hot as the Sun ge....

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01:18:00

What is Quantum Optics?

by Roy Glauber
What is Quantum Optics?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 4045 views
Rating:

The image of light waves as oscillating electromagnetic fields explains virtually all the phenomena of traditional optics.  An awareness that these waves are somehow subdivided into quanta has however been with us since the early 20th century.  The....

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00:43:00

The Development of Particle Physics

by Martinus Veltman
The Development of Particle Physics
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1545 views
Rating:

Particle physics mainly developed after World War II. It has its roots in the first half of the previous century, when it became clear that all matter is made up from atoms, and the atoms in turn were found to contain a nucleus surrounded by electro....

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01:04:00

Mapping the Universe and Its History

by George Smoot
Mapping the Universe and Its History
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2989 views
Rating:

Using our most advanced techniques and instruments we sift through study the cosmic microwave background as a relic of the early universe to understand the events surrounding the birth and subsequent development of the Universe.  A precision inspect....

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00:49:00

Dynamics of Chemical Reactions

by Yuan Lee
Dynamics of Chemical Reactions
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1427 views
Rating:

Every macroscopic chemical transformation, whether it is atmospheric ozone depletion or the burning of a candle, consists of millions of microscopic chemical events, which involve collisions between molecules.  It has been the dream of scientists fo....

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00:35:00

From Disorder to Order

by Gerhard Ertl
From Disorder to Order
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1365 views
Rating:

Our experience suggests that a system will usually show the tendency to undergo spontaneously a transition from the state of order into disorder.  Quite in contrast, our world developed from an initial state of great disorder into another one where ....

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00:40:00

Roles of Protein Degradation in Health and Disease

by Avram Hershko
Roles of Protein Degradation in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2969 views
Rating:

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

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00:45:00

Basic Science and Co-entrepreneurship, my Experience

by Robert Huber
Basic Science and Co-entrepreneurship, my Experience
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1404 views
Rating:

The design and development of inhibiting (or occasionally activating) ligands of target proteins in medicine and crop protection guided by molecular structures and functions has become an established technology in academia and industry recently._ Dr....

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00:54:00

The Revolutionary Impact of the GOOYouWiki World (GYWW) on Education and Student Success

by Harry Kroto
The Revolutionary Impact of the GOOYouWiki World (GYWW) on Education and Student Success
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1861 views
Rating:

Prof. Kroto starts his lecture with remarks on his boyhood and his passions at school and University, especially graphic art and drawing.  He mentions his 4/5 rule and shows the connection between theory and experiments, and he is sold on scientific....

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00:39:00

Molecular Catalysis for Green Chemistry

by Ryoji Noyori
Molecular Catalysis for Green Chemistry
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1521 views
Rating:

Science is inevitably intertwined with society.  The state of the art of science, coupled with industrial endeavors, has determined our quality of life.  Chemists are proud of their ability to generate high value from almost nothing by using accumu....

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00:35:00

Designing Molecules and Nanoparticles to Help See and Treat Disease

by Roger Tsien
Designing Molecules and Nanoparticles to Help See and Treat Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1375 views
Rating:

Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures a....

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00:27:00

Adventures in Nontranslational Research

by Martin Chalfie
Adventures in Nontranslational Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1606 views
Rating:

Professor Martin Chalfie regrets the disproportionately high funding of translational research, defined as applied research for the treatment of human diseases.  With examples from the research in his lab he wants to show how important nontranslatio....

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00:37:00

The Amazing Ribosome

by Ada Yonath
The Amazing Ribosome
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1553 views
Rating:

Ribosomes are the universal cellular machines that act as polymerases that translate the genetic code into proteins. They posses spectacular architecture accompanied by inherent mobility that facilitate their smooth performance in decoding, peptide ....

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00:40:00

Why I love Microbes

by Richard Roberts
Why I love Microbes
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1696 views
Rating:

We live in a fascinating world surrounded by life. Much of that life is clearly visible like the plants and animals that we see every day. However, far more is invisible to the naked eye and it is to this realm, the microscopic world, that I will t....

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00:51:00

Why do we not have a vaccine against TB or HIV (yet)?

by Ralph Zinkernagel
Why do we not have a vaccine against TB or HIV (yet)?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1333 views
Rating:

Survival of vertebrate hosts against infections depends on important natural or innate resistance mechanisms combined with adaptive immune responses of T and B cells. Infectious agents probe the limit of immune responses and help to characterize thr....

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00:46:00

Darwinian evolution as understood by scientists of the 21st century

by Werner Arber
Darwinian evolution as understood by scientists of the 21st century
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1993 views
Rating:

After a short reminder of the historical development of evolutionary biology, elements to a molecular theory of Darwinian evolution will be presented. Biological evolution is driven by the availability of genetic variants in populations. The occasi....

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00:38:00

Protein Crosstalk in Cell Signaling

by Edmond Fischer
Protein Crosstalk in Cell Signaling
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1579 views
Rating:

This talk concentrates on cellular regulation by tyrosine phosphorylation which has been directly implicated in cell growth, differentiation and transformation. Growth factor receptors transduce their signal by recruiting a multiplicity of adaptor p....

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00:12:00

The cell cycle and cancer

by Tim Hunt
The cell cycle and cancer
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2439 views
Rating:

It was in 1882 that Walther Flemming published drawings of chromosomes lining up in mitosis and parting equally to the daughters of cell division, and 20 years later that Theodor Boveri explained the significance of the chromosome dance in terms of t....

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01:05:00

RNAi and development in C. elegans

by Craig Mello
RNAi and development in C. elegans
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2664 views
Rating:

Argonaute proteins interact with small RNAs to mediate gene silencing. C. elegans contains 27 Argonaute homologs, raising the question of what roles these genes play in RNAi and related gene-silencing pathways. Through our collaborator, Dr. Shohei....

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00:51:00

Nitric oxide as a messenger molecule and its role in drug development

by Ferid Murad
Nitric oxide as a messenger molecule and its role in drug development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1662 views
Rating:

The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....

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00:39:00

Recent Advances in Olefin Metathesis Catalyzed by Molybdenum and Tungsten Alkylidene Complexes

by Richard Schrock
Recent Advances in Olefin Metathesis Catalyzed by Molybdenum and Tungsten Alkylidene Complexes
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1788 views
Rating:

In the process of preparing M(NR)(CHCMe2R')(OR")2 (R' = Me or Ph) species (or analogs that contain enantiomerically pure biphenolate or binaphtholate ligands) in situ by treating M(NR)(CHCMe2R')(pyrrolide)2 species with alcohols, we have discovered M....

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00:41:00

Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms

by Roger Tsien
Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1529 views
Rating:

Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures ....

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00:35:00

GFP and After

by Martin Chalfie
GFP and After
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1860 views
Rating:

Since its introduction as a biological marker, the Aequorea victoria Green Fluorescent Protein (GFP) has had a strong impact in biology, being used in an ever-increasing variety of ways. I will review a bit of the history of GFP and show how having ....

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00:26:00

Chemistry of Bioluminescence

by Osamu Shimomura
Chemistry of Bioluminescence
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1556 views
Rating:

There are numerous kinds of luminous organism on earth. Mysterious emission of light from them inspired the curiosity of mankind ever since the ancient times. In history, Raphael Dubois discovered luciferin and luciferase from one of them, a click ....

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00:28:00

Canoeing in the Arctic, a Scientist’s Perspective

by Peter Agre
Canoeing in the Arctic, a Scientist’s Perspective
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1830 views
Rating:

As scientists, our livelihoods are supported by teaching and research, but we also have the opportunity to make observations beyond our usual confines and share these with non-scientific citizens. Growing up in my native state of Minnesota, I have al....

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00:33:00

An Earth Powered Predominantly by Solar and Wind Energy

by Walter Kohn
An Earth Powered Predominantly by Solar and Wind Energy
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1730 views
Rating:

I shall present and explain the thesis that mankind is on the threshold of a dramatic transition: From an earth, predominantly powered by oil and other fossil fuels, with unsustainable global warming, to a new earth predominantly powered by "clean" s....

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