42 results found for lindau-nobel

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00:27:00

Roles of the Ubiquitin System in Health and Disease

by Avram Hershko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1476 views
Rating:

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....

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00:31:00

Structural Aspects of Protease Control in Health and Disease

by Robert Huber
Structural Aspects of Protease Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1476 views
Rating:

This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....

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00:32:00

Aquaporin Water Channels – From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels – From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 3271 views
Rating:

Aquaporin channels allow water to rapidly cross cell membranes in all living organisms. AQP1 confers red cells and proximal renal tubules with high water permeability. Present in renal collecting duct, AQP2 is regulated by vasopressin, and human muta....

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00:32:00

Tickling Worms: Surprises From Basic Research

by Martin Chalfie
Tickling Worms: Surprises From Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1422 views
Rating:

Research, at least my research, has never been linear. I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and peoples interests. This lack of direction....

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00:42:00

Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development

by Ferid Murad
Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 2599 views
Rating:

The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....

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00:34:00

Structural Studies on Cholesterol Transport

by Johann Deisenhofer
Structural Studies on Cholesterol Transport
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 2479 views
Rating:

Cholesterol has two essential functions in our bodies: It is an important component of cell membranes and it serves as the starting material for the synthesis of bile acids, steroid hormones, and other compounds. The human body obtains necessary cho....

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00:29:00

Membrane Proteins: Importance, Functions, Mechanisms

by Hartmut Michel
Membrane Proteins: Importance, Functions, Mechanisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1558 views
Rating:

Biological membranes define and compartmentalize the cells of higher organisms. Consisting of membrane proteins and lipids, they are basically impermeable for ions and polar substances, so that electric voltages (_membrane potentialsî) and substanc....

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00:42:00

Short-term Synaptic Plasticity

by Erwin Neher
Short-term Synaptic Plasticity
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 8253 views
Rating:

Our brain is a network of about 10^11 neurons, which are connected via synapses. A neuron typically receives input from about 10000 other neurons, which can be either excitatory or inhibitory. The neuron integrates these inputs and generates an actio....

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00:34:00

Towards Adaptive Chemistry

by Jean-Marie Lehn
Towards Adaptive Chemistry
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1528 views
Rating:

Supramolecular chemistry lies beyond molecular chemistry. It aims at implementing highly complex chemical systems from molecular components held together by non-covalent intermolecular forces and effecting molecular recognition, catalysis and transp....

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00:33:00

Molecules Against Cancer or for Long-Term Memory Storage

by Roger Tsien
Molecules Against Cancer or for Long-Term Memory Storage
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1797 views
Rating:

For cancer diagnosis and therapy, we are developing activatable cell-penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell-penetrating peptides whose cellular ....

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00:32:00

Aquaporin Water Channels _ From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels _ From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 3701 views
Rating:

Aquaporin (AQP) water channel proteins enable high water permeability in certain biological membranes. Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known. Expres....

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00:39:00

You can see a lot by observing: Optical Microscopy 2.0

by Steve Chu
You can see a lot by observing: Optical Microscopy 2.0
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1570 views
Rating:

Biological research and medicine were transformed by the invention and improvement of the optical microscope. Since the early 1990s, there has been another revolution in optical imaging, and manipulation of individual biological molecules and bio-mo....

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00:28:00

From the Structure of the Ribosome to New Antibiotics

by Thomas Steitz
From the Structure of the Ribosome to New Antibiotics
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1653 views
Rating:

Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanisms of action of a....

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00:31:00

Infections Linked to Human Cancers: Mechanisms and Synergisms

by Harald Zur Hausen
Infections Linked to Human Cancers: Mechanisms and Synergisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1414 views
Rating:

Slightly more than 20% of the global cancer incidence is presently being linked to viral, bacterial, or parasitic infections. The mechanisms by which these agents mediate malignant transformation differ substantially. Some contribute directly, freq....

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00:32:00

Why Do We Not Have a Vaccine Against HIV or Tuberculosis?

by Rolf Zinkernagel
Why Do We Not Have a Vaccine Against HIV or Tuberculosis?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1505 views
Rating:

Analysis of the immune system is fascinating and progressing rapidly. As a field of medical enquiry, it has however, drifted and turned purely academic. This is because interest and appreciation of protective immunity in infectious disease medicine....

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00:32:00

On The Road Toward an HIV Cure

by Franoise BarrŽ-Sinoussi
On The Road Toward an HIV Cure
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1334 views
Rating:

Since the first cases of AIDS in 1981 and the identification of its etiological agent in 1983, much progress has been made in both the development of tools to prevent and treat HIV infection and the access to these tools. In particular, the wide arr....

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00:30:00

Inheritance from Teratomas

by Martin Evans
Inheritance from Teratomas
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1385 views
Rating:

The techniques and concepts that have resulted in the identification and isolation of embryonic stem cells have come from studies with mouse teratocarcinomas. Embryonic stem cells isolated from normal mouse embryos may be grown in tissue culture and....

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00:31:00

Forging a Genetic Paradigm for Cancer

by Michael Bishop
Forging a Genetic Paradigm for Cancer
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1609 views
Rating:

It is now axiomatic that, no matter what its causes, cancer ultimately arises from the malfunction of genes. A number of clues prefigured this paradigm: the persistence of the malignant phenotype through countless cell divisions; the mutagenicity of....

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00:32:00

Man vs. Helicobacter _ The past 50,000 years and the next 50

by Barry Marshall
Man vs. Helicobacter _ The past 50,000 years and the next 50
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1794 views
Rating:

The epidemiology of Helicobacter pylori continues to be an area of discovery and controversy in the 21st century. The transmission of this bacterium from mother to child allows Helicobacter DNA to mimic the evolution of maternal mitochondria DNA. B....

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00:31:00

Deciphering Immunity by Making It Fail

by Bruce Beutler
Deciphering Immunity by Making It Fail
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1752 views
Rating:

Infectious microbes collectively represent the strongest selective pressure operating on our species, and over hundreds of millions of years, drove the evolution of the sophisticated immune system we have today. While the general outlines of immune ....

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00:32:00

Innate Immunity: From Flies to Humans

by Jules Hoffmann
Innate Immunity: From Flies to Humans
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1764 views
Rating:

Flies challenged with bacteria or fungi rapidly transcribe a battery of genes encoding potent antimicrobial peptides which oppose the invading microorganisms. Genetic analysis has identified two signaling cascades which control their expression: (1)....

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00:31:00

Genes and Proteins that Control Secretion and Autophagy

by Randy Schekman
Genes and Proteins that Control Secretion and Autophagy
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 3645 views
Rating:

The broad outlines of the secretory pathway were established by pioneering EM and cell fractionation experiments conducted by George Palade in the 1960s. Beginning in the mid 1970s and early 80s, my laboratory isolated a series of conditionally leth....

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00:40:00

Roles of Protein Degradation in Health and Disease

by Avram Hershko
Roles of Protein Degradation in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2969 views
Rating:

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

More details | Watch now
00:45:00

Basic Science and Co-entrepreneurship, my Experience

by Robert Huber
Basic Science and Co-entrepreneurship, my Experience
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1404 views
Rating:

The design and development of inhibiting (or occasionally activating) ligands of target proteins in medicine and crop protection guided by molecular structures and functions has become an established technology in academia and industry recently._ Dr....

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00:37:00

The Amazing Ribosome

by Ada Yonath
The Amazing Ribosome
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1553 views
Rating:

Ribosomes are the universal cellular machines that act as polymerases that translate the genetic code into proteins. They posses spectacular architecture accompanied by inherent mobility that facilitate their smooth performance in decoding, peptide ....

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00:41:00

Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms

by Roger Tsien
Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1529 views
Rating:

Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures ....

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00:26:00

Chemistry of Bioluminescence

by Osamu Shimomura
Chemistry of Bioluminescence
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1556 views
Rating:

There are numerous kinds of luminous organism on earth. Mysterious emission of light from them inspired the curiosity of mankind ever since the ancient times. In history, Raphael Dubois discovered luciferin and luciferase from one of them, a click ....

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00:36:00

Structural Genomics – Exploring the Protein Universe

by Kurt Wurthrich
Structural Genomics – Exploring the Protein Universe
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1613 views
Rating:

In today's post-genomic era, with the availability of the complete DNA sequences of a wide range of organisms, structural biologists are faced with new opportunities and challenges in _structural genomics”. In contrast to classical structural biol....

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00:31:00

Why Our Proteins Have to Die so We Shall Live

by Aaron Ciechanover
Why Our Proteins Have to Die so We Shall Live
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1485 views
Rating:

Between the sixties and eighties, most life scientists focused their attention on studies of nucleic acids and the translation of the coded information. Protein degradation was a neglected area, considered to be a non-specific, dead-end process. Whil....

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00:42:00

Molecular Machines for Protein Degradation Inside Cells

by Robert Huber
Molecular Machines for Protein Degradation Inside Cells
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1532 views
Rating:

Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic active sites are sequestered within the particles and located on t....

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00:35:00

Proteasome and DegP Protease, Mechanisms and Drug Design

by Robert Huber
Proteasome and DegP Protease, Mechanisms and Drug Design
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1633 views
Rating:

Within cells or subcellular compartments, mis-folded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages, the proteasome and HtrA/DegP.  They are essential components in very complex regul....

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00:29:00

The Ubiquitin Proteolytic System as a Novel Drug Development Platform

by Aaron Ciechanover
The Ubiquitin Proteolytic System as a Novel Drug Development Platform
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1866 views
Rating:

Between the 50s and 80s, most studies in biomedicine focused on the central dogma - the translation of the information coded by DNA to RNA and proteins.  Protein degradation was a neglected area, considered to be a non-specific, dead-end process.  ....

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00:28:00

Roles of the Ubiquitin System in Health and Disease

by Avram Herschko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1534 views
Rating:

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

More details | Watch now
00:33:00

Engineering Molecules for Fun, Profit, and Clinical Relevance

by Roger Tsien
Engineering Molecules for Fun, Profit, and Clinical Relevance
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1284 views
Rating:

Molecules to observe and manipulate biological systems and disease processes can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution.  Examples of both ....

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00:32:00

The Fuel of Life

by John Walker
The Fuel of Life
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1421 views
Rating:

The lecture will be devoted to the topic of how the biological world supplies itself with energy to make biology work, and what medical consequences ensue when the energy supply chain in our bodies is damaged or defective.  We derive our energy from....

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00:33:00

Curiosity and its Fruits: From Basic Science to Advanced Medicine

by Ada Yonath
Curiosity and its Fruits: From Basic Science to Advanced Medicine
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1486 views
Rating:

Ribosomes, the universal cellular machines that translate the genetic code into proteins, are targeted by many antibiotics that paralyze them by binding to their functional sites.  Antibiotics binding modes, inhibitory actions and synergism pathways....

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00:35:00

Structure and Mechanism of Otto Warburg’s Respiratory Enzyme, the Cytochrome c Oxidase

by Hartmut Michel
Structure and Mechanism of Otto Warburg’s Respiratory Enzyme, the Cytochrome c Oxidase
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2075 views
Rating:

The oxygen, you breathe in, is converted to water by cytochrome c oxidase, using electrons provided by cytochrome c and protons from the aqueous milieu of the body.  This fundamental enzyme has been discovered already in 1886, and studied extensivel....

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00:38:00

Conformational Plasticity of G-Protein-Coupled Receptors (GPCRs) studied by NMR in Solution

by Kurt Wurthrich
Conformational Plasticity of G-Protein-Coupled Receptors (GPCRs) studied by NMR in Solution
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1633 views
Rating:

As an introduction, some principles of nuclear spin physics applying to studies of integral membrane proteins (IMP) will be reviewed.  Applications of resulting nuclear magnetic resonance (NMR) techniques will then be illustrated with studies of G-p....

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00:32:00

Tickling Worms: Surprises From Basic Research

by Martin Chalfie
Tickling Worms: Surprises From Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1978 views
Rating:

Research, at least my research, has never been linear.  I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and people's interests.  This lack of direct....

More details | Watch now
00:30:00

Aquaporin Water Channels: From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels: From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2871 views
Rating:

Aquaporin (AQP) water channel proteins enable high water permeability of certain biological membranes.  Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known.  Expr....

More details | Watch now
00:34:00

Proteases and Their Control in Health and Disease

by Robert Huber
Proteases and Their Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1385 views
Rating:

Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic cleavage of a peptide bond.  Nevertheless, they constitute a most diverse and numerous lineage of proteins.  The reason lies in their role as components of many regulatory....

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00:33:00

The Ubiquitin System

by Avram Hershko
The Ubiquitin System
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1442 views
Rating:

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

More details | Watch now

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