Structural Aspects of Protease Control in Health and Disease

View Structural Aspects of Protease Control in Health and Disease

Presenter: Robert Huber

Published: July 2015

Age: 18-22 and upwards

Views: 705 views

Tags: proteolytic;protein;x-ray;crystallography;

Type: Lectures

Source/institution: Lindau-Nobel


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This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic cleavage of a peptide bond. Nevertheless they constitute a most diverse and numerous lineage of proteins. The reason lies in their role as components of many regulatory physiological cascades in all organisms. To serve this purpose and to avoid unwanted destructive action, proteolytic activity must be strictly controlled.