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00:27:00

Roles of the Ubiquitin System in Health and Disease

by Avram Hershko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 4 years ago | 640 views
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The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....

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00:31:00

Structural Aspects of Protease Control in Health and Disease

by Robert Huber
Structural Aspects of Protease Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 4 years ago | 606 views
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This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....

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00:32:00

Aquaporin Water Channels – From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels – From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 4 years ago | 869 views
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Aquaporin channels allow water to rapidly cross cell membranes in all living organisms. AQP1 confers red cells and proximal renal tubules with high water permeability. Present in renal collecting duct, AQP2 is regulated by vasopressin, and human muta....

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00:32:00

Tickling Worms: Surprises From Basic Research

by Martin Chalfie
Tickling Worms: Surprises From Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 611 views
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Research, at least my research, has never been linear. I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and peoples interests. This lack of direction....

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00:42:00

Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development

by Ferid Murad
Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 1115 views
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The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....

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00:34:00

Structural Studies on Cholesterol Transport

by Johann Deisenhofer
Structural Studies on Cholesterol Transport
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 626 views
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Cholesterol has two essential functions in our bodies: It is an important component of cell membranes and it serves as the starting material for the synthesis of bile acids, steroid hormones, and other compounds. The human body obtains necessary cho....

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00:29:00

Membrane Proteins: Importance, Functions, Mechanisms

by Hartmut Michel
Membrane Proteins: Importance, Functions, Mechanisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 617 views
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Biological membranes define and compartmentalize the cells of higher organisms. Consisting of membrane proteins and lipids, they are basically impermeable for ions and polar substances, so that electric voltages (_membrane potentialsî) and substanc....

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00:42:00

Short-term Synaptic Plasticity

by Erwin Neher
Short-term Synaptic Plasticity
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 4600 views
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Our brain is a network of about 10^11 neurons, which are connected via synapses. A neuron typically receives input from about 10000 other neurons, which can be either excitatory or inhibitory. The neuron integrates these inputs and generates an actio....

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00:34:00

Towards Adaptive Chemistry

by Jean-Marie Lehn
Towards Adaptive Chemistry
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 662 views
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Supramolecular chemistry lies beyond molecular chemistry. It aims at implementing highly complex chemical systems from molecular components held together by non-covalent intermolecular forces and effecting molecular recognition, catalysis and transp....

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00:33:00

Molecules Against Cancer or for Long-Term Memory Storage

by Roger Tsien
Molecules Against Cancer or for Long-Term Memory Storage
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 690 views
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For cancer diagnosis and therapy, we are developing activatable cell-penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell-penetrating peptides whose cellular ....

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00:32:00

Aquaporin Water Channels _ From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels _ From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 2240 views
Rating:

Aquaporin (AQP) water channel proteins enable high water permeability in certain biological membranes. Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known. Expres....

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00:39:00

You can see a lot by observing: Optical Microscopy 2.0

by Steve Chu
You can see a lot by observing: Optical Microscopy 2.0
for 18-22 and upwards,
Lectures | 18-22 and upwards | 5 years ago | 749 views
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Biological research and medicine were transformed by the invention and improvement of the optical microscope. Since the early 1990s, there has been another revolution in optical imaging, and manipulation of individual biological molecules and bio-mo....

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