
Future Accelerators for Astro-Particle Physics
One of the most remarkable results of astro-particle Physics has been the success of the Standard Model, recently culminated in the discovery of the Higgs particle (Ho). However, the Ho is observable only in few channels at the LHC, in the presence o....
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The International Year of Light: Celebrating Fifty Years of Laser Revolution in Physics
The year 2015 has been named the International Year of Light, to mark milestones in the science of light which occurred 1000, 200, 150, 100 and 50 years go. I was a young student in physics in 1965, when the cosmic radiation background was discovered....
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Light Quanta and Their Idiosyncrasies
Maxwell's electromagnetic theory (now 150 years old) seemed in its comprehensive way to be capable of answering all of the questions one might ever pose about the theory of light. But that spell was broken in 1900 by Planck's discovery that light bea....
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Quantum Information: a Scientific and Technological Revolution for the 21st Century
Two of the great scientific and technical revolutions of the 20th century were the discovery of the quantum nature of the submicroscopic world, and the advent of information science and engineering. Both of these have had a profound effect not only o....
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Science with Combs of Light
The spectrum of a frequency comb, commonly generated by a mode-locked femtosecond laser, consists of several hundred thousand precisely evenly spaced spectral lines. Such laser frequency combs have revolutionized the art of measuring the frequency of....
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What We Learn When We Learn that the Universe is Accelerating
The 1998 discovery that the universe's expansion is accelerating was not only unexpected, but it also led to the postulation of a previously-unknown 'dark energy' forming almost three-quarters of the "stuff" of the universe. How was this discovery ma....
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The Origin of Elementary Particle Masses
In the beginning of the 60s, the laws of classical general relativity, Einstein's generalisation of Newtonian gravity, and of quantum electrodynamics, the quantum version of Maxwell's electromagnetic theory, were known. These laws describe long range....
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Nanoscopy – allowing molecules to be examined inside living cells
Eric Betzig shared the 2014 Chemistry Nobel prize with fellow American William E. Moerner and Romanian-German Stefan W. Hell for revolutionising science through the development of super-resolved fluorescence to exceed the accepted limits of tradition....
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The Hunt May Be Up for the Carrier of the Diffuse Interstellar Bands and other stories
The development of radio telescopes has revolutionized our understanding of the molecular constitution of the interstellar medium ISM. A recent surprise that the element carbon had up its sleeve was the existence of C60, Buckminsterfullerene, the thi....
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Fun with Light and Single Molecules
More than 25 years ago, single molecules were first detected optically, but how do we really detect a single molecule today, and what good is it? It is an amazing fact that you can even detect single molecules with your own eyes. When a new regime of....
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Tickling Worms – Surprises from Basic Research
Research, at least my research, has never been linear. I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and people's interests This lack of direction r....
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How to Model the Action of Complex Biological Systems on a Molecular Level
Despite the enormous advances in structural studies of biological systems we are frequently left without a clear structure function correlation and cannot fully describe how different systems actually work. This introduces a major challenge for compu....
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Electron Transfer Theory in Single Molecule Studies of Intermittent Fluorescence of Quantum Dots and in Initial Steps in Dye Sensitized Solar Cells
Intermittently fluorescing single molecule systems are found in many materials, including semiconductor quantum dots (QD), dyes on crystalline or nanoparticle film surfaces, and biological systems. The QD's show a ~ -3/2 power law for the distributio....
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Molecules Against Cancer or for Long-Term Memory Storage
For cancer diagnosis and therapy, we are developing activatable cell penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell penetrating peptides whose cellular u....
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NMR in Biology, Chemistry and Medicine
For the discovery of the physics phenomenon of nuclear magnetic resonance (NMR), Felix Bloch and Edward Purcell were awarded the Nobel Prize in Physics in 1952. NMR has then been used in a wide range of fundamental studies in physics, and in the 1960....
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Quasi-Periodic Crystals
Quasicrystals - or, as Shechtman would prefer, quasi-periodic materials - now have scientists thinking about matter in a new light, but they also have many possible practical applications. Because of their uneven structure, quasicrystals do not have ....
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Are We Going to Cure all Diseases and at What Price?
We are exiting the era where our approach to treatment of these and many other diseases is 'one size fits all', and enter a new era of 'personalized medicine' where we shall tailor the treatment according to the patient's molecular/mutational profile....
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How to Synthesize a Wide Variety of Optically Active Compounds with >99% Optical Purity
The discovery and synthetic applications of a widely applicable and highly enantioselective (>99% ee) protocol consisting of the 'ZACA reaction' (Zr-catalyzed asymmetric carboalumination of alkenes), purification of the ZACA-products by lipase-cat....
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Catalysis at Surfaces: From Atoms to Complexity
This lecture addresses the question if spatio-temporal self-organisation of matter which is so characteristic for living systems can also be verified with a simple inorganic reaction in which the observed phenomena of complexity can be traced back to....
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Roles of the Ubiquitin System in Health and Disease
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....
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Structural Aspects of Protease Control in Health and Disease
This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....
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Where am I From? Where Are You Going?
Scientific research is a never-ending 'journey of knowledge'. There is more meaning in experiencing various encounters and making a good journey itself than reaching the destination. Basic science has eternal cultural value; it has served to heighten....
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Towards Adaptive Chemistry
Molecular chemistry implementing reversible chemical bonds between atoms in molecules, as well as supramolecular chemistry, whose molecular components are held together by intermolecular interactions, are able to undergo a continuous change in consti....
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Aquaporin Water Channels – From Atomic Structure to Malaria
Aquaporin channels allow water to rapidly cross cell membranes in all living organisms. AQP1 confers red cells and proximal renal tubules with high water permeability. Present in renal collecting duct, AQP2 is regulated by vasopressin, and human muta....
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