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Despite the enormous advances in structural studies of biological systems we are frequently left without a clear structure function correlation and cannot fully describe how different systems actually work. This introduces a major challenge for compu....

Intermittently fluorescing single molecule systems are found in many materials, including semiconductor quantum dots (QD), dyes on crystalline or nanoparticle film surfaces, and biological systems. The QD's show a ~ -3/2 power law for the distributio....

For cancer diagnosis and therapy, we are developing activatable cell penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell penetrating peptides whose cellular u....

For the discovery of the physics phenomenon of nuclear magnetic resonance (NMR), Felix Bloch and Edward Purcell were awarded the Nobel Prize in Physics in 1952. NMR has then been used in a wide range of fundamental studies in physics, and in the 1960....

Quasicrystals - or, as Shechtman would prefer, quasi-periodic materials - now have scientists thinking about matter in a new light, but they also have many possible practical applications. Because of their uneven structure, quasicrystals do not have ....

We are exiting the era where our approach to treatment of these and many other diseases is 'one size fits all', and enter a new era of 'personalized medicine' where we shall tailor the treatment according to the patient's molecular/mutational profile....

The discovery and synthetic applications of a widely applicable and highly enantioselective (>99% ee) protocol consisting of the 'ZACA reaction' (Zr-catalyzed asymmetric carboalumination of alkenes), purification of the ZACA-products by lipase-cat....

This lecture addresses the question if spatio-temporal self-organisation of matter which is so characteristic for living systems can also be verified with a simple inorganic reaction in which the observed phenomena of complexity can be traced back to....

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....

This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....

Scientific research is a never-ending 'journey of knowledge'. There is more meaning in experiencing various encounters and making a good journey itself than reaching the destination. Basic science has eternal cultural value; it has served to heighten....

Molecular chemistry implementing reversible chemical bonds between atoms in molecules, as well as supramolecular chemistry, whose molecular components are held together by intermolecular interactions, are able to undergo a continuous change in consti....