42 results found for lindau-nobel

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00:28:00

From the Structure of the Ribosome to New Antibiotics

by Thomas Steitz
From the Structure of the Ribosome to New Antibiotics
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1653 views
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Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanisms of action of a....

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00:31:00

Infections Linked to Human Cancers: Mechanisms and Synergisms

by Harald Zur Hausen
Infections Linked to Human Cancers: Mechanisms and Synergisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1414 views
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Slightly more than 20% of the global cancer incidence is presently being linked to viral, bacterial, or parasitic infections. The mechanisms by which these agents mediate malignant transformation differ substantially. Some contribute directly, freq....

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00:32:00

Why Do We Not Have a Vaccine Against HIV or Tuberculosis?

by Rolf Zinkernagel
Why Do We Not Have a Vaccine Against HIV or Tuberculosis?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1505 views
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Analysis of the immune system is fascinating and progressing rapidly. As a field of medical enquiry, it has however, drifted and turned purely academic. This is because interest and appreciation of protective immunity in infectious disease medicine....

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00:32:00

On The Road Toward an HIV Cure

by Franoise BarrŽ-Sinoussi
On The Road Toward an HIV Cure
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1333 views
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Since the first cases of AIDS in 1981 and the identification of its etiological agent in 1983, much progress has been made in both the development of tools to prevent and treat HIV infection and the access to these tools. In particular, the wide arr....

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00:30:00

Inheritance from Teratomas

by Martin Evans
Inheritance from Teratomas
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1385 views
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The techniques and concepts that have resulted in the identification and isolation of embryonic stem cells have come from studies with mouse teratocarcinomas. Embryonic stem cells isolated from normal mouse embryos may be grown in tissue culture and....

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00:31:00

Forging a Genetic Paradigm for Cancer

by Michael Bishop
Forging a Genetic Paradigm for Cancer
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1608 views
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It is now axiomatic that, no matter what its causes, cancer ultimately arises from the malfunction of genes. A number of clues prefigured this paradigm: the persistence of the malignant phenotype through countless cell divisions; the mutagenicity of....

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00:32:00

Man vs. Helicobacter _ The past 50,000 years and the next 50

by Barry Marshall
Man vs. Helicobacter _ The past 50,000 years and the next 50
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1793 views
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The epidemiology of Helicobacter pylori continues to be an area of discovery and controversy in the 21st century. The transmission of this bacterium from mother to child allows Helicobacter DNA to mimic the evolution of maternal mitochondria DNA. B....

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00:31:00

Deciphering Immunity by Making It Fail

by Bruce Beutler
Deciphering Immunity by Making It Fail
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1752 views
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Infectious microbes collectively represent the strongest selective pressure operating on our species, and over hundreds of millions of years, drove the evolution of the sophisticated immune system we have today. While the general outlines of immune ....

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00:32:00

Innate Immunity: From Flies to Humans

by Jules Hoffmann
Innate Immunity: From Flies to Humans
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 1764 views
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Flies challenged with bacteria or fungi rapidly transcribe a battery of genes encoding potent antimicrobial peptides which oppose the invading microorganisms. Genetic analysis has identified two signaling cascades which control their expression: (1)....

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00:31:00

Genes and Proteins that Control Secretion and Autophagy

by Randy Schekman
Genes and Proteins that Control Secretion and Autophagy
for 18-22 and upwards,
Lectures | 18-22 and upwards | 10 years ago | 3645 views
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The broad outlines of the secretory pathway were established by pioneering EM and cell fractionation experiments conducted by George Palade in the 1960s. Beginning in the mid 1970s and early 80s, my laboratory isolated a series of conditionally leth....

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00:40:00

Roles of Protein Degradation in Health and Disease

by Avram Hershko
Roles of Protein Degradation in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 2969 views
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The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

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00:45:00

Basic Science and Co-entrepreneurship, my Experience

by Robert Huber
Basic Science and Co-entrepreneurship, my Experience
for 18-22 and upwards,
Lectures | 18-22 and upwards | 11 years ago | 1404 views
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The design and development of inhibiting (or occasionally activating) ligands of target proteins in medicine and crop protection guided by molecular structures and functions has become an established technology in academia and industry recently._ Dr....

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