How to Synthesize a Wide Variety of Optically Active Compounds with >99% Optical Purity
View How to Synthesize a Wide Variety of Optically Active Compounds with >99% Optical Purity
Presenter: Ei-ichi Negishi
Published: July 2015
Age: 18-22 and upwards
Views: 1726 views
Tags: optical;active;enantiomer;catalysis;chiral
Type: Lectures
Source/institution: Lindau-Nobel
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The discovery and synthetic applications of a widely applicable and highly enantioselective (>99% ee) protocol consisting of the ‘ZACA reaction’ (Zr-catalyzed asymmetric carboalumination of alkenes), purification of the ZACA-products by lipase-catalyzed acetylation, and subsequent transformations, such as Pd- or Cu-catalyzed cross-coupling, are discussed. We now believe that one of the last bastions in organic synthesis may have been conquered.
