Molecules Against Cancer or for Long-Term Memory Storage
Presenter: Roger Tsien
Published: July 2015
Age: 18-22 and upwards
Views: 1368 views
Tags: cell;peptide;polycation;protease;ACCP;memory;synapse
Type: Lectures
Source/institution: Lindau-Nobel
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For cancer diagnosis and therapy, we are developing activatable cell penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell penetrating peptides whose cellular uptake is minimized by a polyanionic inhibitory domain and restored if the peptide linker connecting the two domains is cleaved. Local activity of specific proteases cuts the linker and causes amplified adhesion and uptake in tumors. ACPPs sensitive to matrix metalloproteinases 2 and -9 enable magnetic resonance imaging (MRI), fluorescence-guided surgery, delivery of chemotherapy, and radiosensitization.
