Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development
The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....
More details | Watch nowFrom the Structure of the Ribosome to New Antibiotics
Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanisms of action of a....
More details | Watch nowInfections Linked to Human Cancers: Mechanisms and Synergisms
Slightly more than 20% of the global cancer incidence is presently being linked to viral, bacterial, or parasitic infections. The mechanisms by which these agents mediate malignant transformation differ substantially. Some contribute directly, freq....
More details | Watch nowWhy Do We Not Have a Vaccine Against HIV or Tuberculosis?
Analysis of the immune system is fascinating and progressing rapidly. As a field of medical enquiry, it has however, drifted and turned purely academic. This is because interest and appreciation of protective immunity in infectious disease medicine....
More details | Watch nowMan vs. Helicobacter _ The past 50,000 years and the next 50
The epidemiology of Helicobacter pylori continues to be an area of discovery and controversy in the 21st century. The transmission of this bacterium from mother to child allows Helicobacter DNA to mimic the evolution of maternal mitochondria DNA. B....
More details | Watch nowInnate Immunity: From Flies to Humans
Flies challenged with bacteria or fungi rapidly transcribe a battery of genes encoding potent antimicrobial peptides which oppose the invading microorganisms. Genetic analysis has identified two signaling cascades which control their expression: (1)....
More details | Watch nowChemistry of Bioluminescence
There are numerous kinds of luminous organism on earth. Mysterious emission of light from them inspired the curiosity of mankind ever since the ancient times. In history, Raphael Dubois discovered luciferin and luciferase from one of them, a click ....
More details | Watch nowCuriosity and its Fruits: From Basic Science to Advanced Medicine
Ribosomes, the universal cellular machines that translate the genetic code into proteins, are targeted by many antibiotics that paralyze them by binding to their functional sites. Antibiotics binding modes, inhibitory actions and synergism pathways....
More details | Watch nowStructure and Mechanism of Otto Warburg’s Respiratory Enzyme, the Cytochrome c Oxidase
The oxygen, you breathe in, is converted to water by cytochrome c oxidase, using electrons provided by cytochrome c and protons from the aqueous milieu of the body. This fundamental enzyme has been discovered already in 1886, and studied extensivel....
More details | Watch now