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Ribosomes are the universal cellular machines that act as polymerases that translate the genetic code into proteins. They posses spectacular architecture accompanied by inherent mobility that facilitate their smooth performance in decoding, peptide ....

Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures ....

There are numerous kinds of luminous organism on earth. Mysterious emission of light from them inspired the curiosity of mankind ever since the ancient times. In history, Raphael Dubois discovered luciferin and luciferase from one of them, a click ....

In today's post-genomic era, with the availability of the complete DNA sequences of a wide range of organisms, structural biologists are faced with new opportunities and challenges in _structural genomics”. In contrast to classical structural biol....

Between the sixties and eighties, most life scientists focused their attention on studies of nucleic acids and the translation of the coded information. Protein degradation was a neglected area, considered to be a non-specific, dead-end process. Whil....

Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic active sites are sequestered within the particles and located on t....

Within cells or subcellular compartments, mis-folded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages, the proteasome and HtrA/DegP.  They are essential components in very complex regul....

Between the 50s and 80s, most studies in biomedicine focused on the central dogma - the translation of the information coded by DNA to RNA and proteins.  Protein degradation was a neglected area, considered to be a non-specific, dead-end process.  ....

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

Molecules to observe and manipulate biological systems and disease processes can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution.  Examples of both ....

The lecture will be devoted to the topic of how the biological world supplies itself with energy to make biology work, and what medical consequences ensue when the energy supply chain in our bodies is damaged or defective.  We derive our energy from....

Ribosomes, the universal cellular machines that translate the genetic code into proteins, are targeted by many antibiotics that paralyze them by binding to their functional sites.  Antibiotics binding modes, inhibitory actions and synergism pathways....