Bacterial cell walls, antibiotics and the origins of life
The cell wall is a crucial structure found in almost all bacteria. It is the target for our best antibiotics and fragments of the wall trigger powerful innate immune responses against infection. Surprisingly, many bacteria can switch almost effortl....
More details | Watch nowAntibiotic Resistance
From the Structure of the Ribosome to the Design of New Antibiotics
Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanism of action of a ....
More details | Watch nowClimbing the Everest Beyond the Everest
The challenges associated with pursuing ribosomal crystallography can be described as a series of Everest climbing. At each step, when reaching the summit, a taller and more difficult one became exposed. Snapshots of this story will be described.__....
More details | Watch nowFrom the Structure of the Ribosome to New Antibiotics
Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanisms of action of a....
More details | Watch nowThe Amazing Ribosome
Ribosomes are the universal cellular machines that act as polymerases that translate the genetic code into proteins. They posses spectacular architecture accompanied by inherent mobility that facilitate their smooth performance in decoding, peptide ....
More details | Watch nowProteasome and DegP Protease, Mechanisms and Drug Design
Within cells or subcellular compartments, mis-folded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages, the proteasome and HtrA/DegP. They are essential components in very complex regul....
More details | Watch nowCuriosity and its Fruits: From Basic Science to Advanced Medicine
Ribosomes, the universal cellular machines that translate the genetic code into proteins, are targeted by many antibiotics that paralyze them by binding to their functional sites. Antibiotics binding modes, inhibitory actions and synergism pathways....
More details | Watch nowFrom bears’ winter-sleep to advanced antibiotics
Professor Ada Yonath, Weizmann Institute of Science, Israel. To facilitate instant recovery of active life once bears wake up from their winter sleep, nature provides ingenious mechanism based on periodic packing of their ribosomes, the cellular ma....
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Contagions, or infectious diseases, which kill both fascinate and frighten us. Far from receding in importance as was expected fifty years ago in the heyday of new antibiotic discovery, infectious diseases remain a major cause of suffering and death ....
More details | Watch nowThe Development, Use and Impact of Penicillin
Lucas Paladino gives a brief overview of the development, use and impact of penicillin.
More details | Watch nowThe Development, Treatment and Future of Antibiotic Resistance in Bacteria.
Branden Anglin presents on the development, treatment and possible future of antibiotic resistance in bacteria.
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