Telomeres: Telling Tails
Telomeres protect chromosome ends and help stabilize the genome. Throughout human life and in aging, telomeres often erode down, eventually causing cells to malfunction or die. The highly regulated cellular enzyme telomerase adds telomeric DNA to tel....
More details | Watch nowThe Killer Defence
Immune surveillance by virus-specific CD8+ cytotoxic T lymphocytes (CTLs), or killer T cells, has long been known to be central to the control of acute infections and some cancers, though the role of CTL memory in the rapid recall of immune protectio....
More details | Watch nowFrom Proto-oncogenes to Precision Oncology
The diagnosis, classification, and treatment of human cancers are being transformed by scientific discoveries that were strongly influenced by the discovery of the c-src proto-oncogene, as described in the lecture by Michael Bishop. The path to this ....
More details | Watch nowMolecules Against Cancer or for Long-Term Memory Storage
For cancer diagnosis and therapy, we are developing activatable cell penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell penetrating peptides whose cellular u....
More details | Watch nowRoles of the Ubiquitin System in Health and Disease
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....
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Genetic control and the mammalian radiation
To grow tissues in our body two key types of DNA control how, where and when to build essential proteins. Recent comparisons of mammal genomes show that instructions coding how to build proteins are similar across diverse species. In contrast the gen....
More details | Watch nowTargeting the human kinome: cancer drug discovery
This lecture discusses how the discovery of the Philadelphia chromosome provided the first example of a link between cancer and a recurrent genetic abnormality. This chromosomal translocation, which results in activation of the Abl protein kinase, re....
More details | Watch nowProgrammed Cell Death in Development and Disease
Programmed cell death (often referred to as apoptosis) is a normal feature of animal development and tissue homeostasis. The misregulation of cell death has been implicated in a diversity of human disorders, including cancer, autoimmune diseases, he....
More details | Watch nowDiscovery of Nitric Oxide and Cyclic GMP in Cell Signalling and their Role in Drug Development
The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....
More details | Watch nowInfections in the Etiology of Human Cancers
During the past century a number of chemical and physical risk factors for human cancers have been identified. Only relatively recently, mainly during the past 30 years, infectious agents have been identified as important human carcinogens. Besides....
More details | Watch nowTelomeres and Telomerase in Human Health and Disease
Telomeres are the protective tips that stabilize the ends of chromosomes. The function of telomeres is to allow cells to divide while holding the genetic material intact. Telomeres contain specialized, simple repetitive DNA sequences that, together....
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