88 results found for disease

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00:51:00

Why do we not have a vaccine against TB or HIV (yet)?

by Ralph Zinkernagel
Why do we not have a vaccine against TB or HIV (yet)?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1204 views
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Survival of vertebrate hosts against infections depends on important natural or innate resistance mechanisms combined with adaptive immune responses of T and B cells. Infectious agents probe the limit of immune responses and help to characterize thr....

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00:51:00

Nitric oxide as a messenger molecule and its role in drug development

by Ferid Murad
Nitric oxide as a messenger molecule and its role in drug development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1377 views
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The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....

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00:31:00

Why Our Proteins Have to Die so We Shall Live

by Aaron Ciechanover
Why Our Proteins Have to Die so We Shall Live
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1337 views
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Between the sixties and eighties, most life scientists focused their attention on studies of nucleic acids and the translation of the coded information. Protein degradation was a neglected area, considered to be a non-specific, dead-end process. Whil....

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00:30:00

Photosynthesis, Biomass, Biofuels: Conversion Efficiencies and Consequences

by Hartmut Michel
Photosynthesis, Biomass, Biofuels: Conversion Efficiencies and Consequences
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1304 views
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It is generally accepted that the global warming, which we undoubtedly observe, is the result of an increased concentration of greenhouse gases like carbon dioxide and methane in the atmosphere.  Within this scenario it is evident that we have to re....

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00:29:00

The Ubiquitin Proteolytic System as a Novel Drug Development Platform

by Aaron Ciechanover
The Ubiquitin Proteolytic System as a Novel Drug Development Platform
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1689 views
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Between the 50s and 80s, most studies in biomedicine focused on the central dogma - the translation of the information coded by DNA to RNA and proteins.  Protein degradation was a neglected area, considered to be a non-specific, dead-end process.  ....

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00:28:00

Roles of the Ubiquitin System in Health and Disease

by Avram Herschko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1324 views
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The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system.  In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved sma....

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00:33:00

Engineering Molecules for Fun, Profit, and Clinical Relevance

by Roger Tsien
Engineering Molecules for Fun, Profit, and Clinical Relevance
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1141 views
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Molecules to observe and manipulate biological systems and disease processes can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution.  Examples of both ....

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00:32:00

The Fuel of Life

by John Walker
The Fuel of Life
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1283 views
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The lecture will be devoted to the topic of how the biological world supplies itself with energy to make biology work, and what medical consequences ensue when the energy supply chain in our bodies is damaged or defective.  We derive our energy from....

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00:27:00

G Protein Coupled Receptors: Challenges for Drug Discovery

by Brian Kobilka
G Protein Coupled Receptors: Challenges for Drug Discovery
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1433 views
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G protein coupled receptors (GPCRs) conduct the majority of cellular responses to hormones and neurotransmitters, and are therefore the largest group of pharmaceutical targets for a broad spectrum of diseases.  Identification of genes for GPCRs, ini....

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00:34:00

Drug Development in the 21st Century – Are We Going to Cure All Diseases?

by Aaron Ciechanover
Drug Development in the 21st Century – Are We Going to Cure All Diseases?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1943 views
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Many important drugs such as penicillin, aspirin, or digitalis, were discovered by serendipity - some by curious researchers who accidentally noted a "strange" phenomenon, and some by isolation of active ingredients form plants known for centuries to....

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00:32:00

Tickling Worms: Surprises From Basic Research

by Martin Chalfie
Tickling Worms: Surprises From Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1746 views
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Research, at least my research, has never been linear.  I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and people's interests.  This lack of direct....

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00:34:00

Proteases and Their Control in Health and Disease

by Robert Huber
Proteases and Their Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1249 views
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Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic cleavage of a peptide bond.  Nevertheless, they constitute a most diverse and numerous lineage of proteins.  The reason lies in their role as components of many regulatory....

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