5 results found for genetica

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01:13:00

Targeting the human kinome: cancer drug discovery

by Nicholas Lydon
Targeting the human kinome: cancer drug discovery
for 14-19 and upwards,
Lectures | 14-19 and upwards | 9 years ago | 1122 views
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This lecture discusses how the discovery of the Philadelphia chromosome provided the first example of a link between cancer and a recurrent genetic abnormality. This chromosomal translocation, which results in activation of the Abl protein kinase, re....

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00:33:00

Programmed Cell Death in Development and Disease

by Robert Horvitz
Programmed Cell Death in Development and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1888 views
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Programmed cell death (often referred to as apoptosis) is a normal feature of animal development and tissue homeostasis. The misregulation of cell death has been implicated in a diversity of human disorders, including cancer, autoimmune diseases, he....

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00:31:00

Forging a Genetic Paradigm for Cancer

by Michael Bishop
Forging a Genetic Paradigm for Cancer
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1384 views
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It is now axiomatic that, no matter what its causes, cancer ultimately arises from the malfunction of genes. A number of clues prefigured this paradigm: the persistence of the malignant phenotype through countless cell divisions; the mutagenicity of....

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00:41:00

Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms

by Roger Tsien
Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1385 views
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Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures ....

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00:35:00

GFP and After

by Martin Chalfie
GFP and After
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1696 views
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Since its introduction as a biological marker, the Aequorea victoria Green Fluorescent Protein (GFP) has had a strong impact in biology, being used in an ever-increasing variety of ways. I will review a bit of the history of GFP and show how having ....

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