75 results found for disease

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00:35:00

Telomeres: Telling Tails

by Elizabeth Blackburn
Telomeres: Telling Tails
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1849 views
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Telomeres protect chromosome ends and help stabilize the genome. Throughout human life and in aging, telomeres often erode down, eventually causing cells to malfunction or die. The highly regulated cellular enzyme telomerase adds telomeric DNA to tel....

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00:30:00

Ion Channels: Their Discovery, their Function and their Role in Diseases

by Erwin Neher
Ion Channels: Their Discovery, their Function and their Role in Diseases
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1559 views
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The concept of bioelectricity emerged in the late 18th century, based on the experiments of Galvani and Volta. Sixty years ago, Hodgkin and Huxley showed that the nerve impulse is a result of permeability changes of the nerve membrane. This raised th....

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00:30:00

The Origin of Reversible Protein Phosphorylation as a Regulatory Mechanism

by Edmond Fischer
The Origin of Reversible Protein Phosphorylation as a Regulatory Mechanism
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1658 views
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Reversible protein phosphorylation can be considered one of the most prevalent mechanism by which eukaryotic cellular events are regulated. It is directly involved in numerous pathological conditions, and bacterial and viral diseases. This process wa....

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00:31:00

Finding Mutations that Affect Immunity

by Bruce Beutler
Finding Mutations that Affect Immunity
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1606 views
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Beginning with an exception to normal function caused by a genetic aberration, one may hope to find at least one protein with non-redundant function in a certain biological process. This approach permitted the identification of the receptor for bacte....

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00:32:00

Tickling Worms – Surprises from Basic Research

by Martin Chalfie
Tickling Worms – Surprises from Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1350 views
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Research, at least my research, has never been linear. I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and people's interests This lack of direction r....

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00:33:00

Molecules Against Cancer or for Long-Term Memory Storage

by Roger Tsien
Molecules Against Cancer or for Long-Term Memory Storage
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1188 views
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For cancer diagnosis and therapy, we are developing activatable cell penetrating peptides (ACPPs), synthetic molecules with a novel amplifying mechanism for homing to diseased tissues. ACPPs are polycationic cell penetrating peptides whose cellular u....

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00:29:00

Are We Going to Cure all Diseases and at What Price?

by Aaron Ciechanover
Are We Going to Cure all Diseases and at What Price?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1708 views
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We are exiting the era where our approach to treatment of these and many other diseases is 'one size fits all', and enter a new era of 'personalized medicine' where we shall tailor the treatment according to the patient's molecular/mutational profile....

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00:27:00

Roles of the Ubiquitin System in Health and Disease

by Avram Hershko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1299 views
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The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....

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00:31:00

Structural Aspects of Protease Control in Health and Disease

by Robert Huber
Structural Aspects of Protease Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1297 views
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This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....

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01:16:00

The End of Disease

by Roger Kornberg
The End of Disease
for 14-19 and upwards,
Lectures | 14-19 and upwards | 9 years ago | 1647 views
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The importance of transcription in cells and its effect on disease.

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01:00:00

Harnessing the power of mobile phones and big data for global health

by Rachel McKendry
Harnessing the power of mobile phones and big data for global health
for 14-19 and upwards,
Lectures | 14-19 and upwards | 9 years ago | 1319 views
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Infectious diseases rank among the gravest threats to human health alongside global warming and terrorism. New strains continue to evolve every year and can spread rapidly. The consequences can be devastating. The 1918 Spanish flu killed an estimated....

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00:31:00

HIV, a Discovery Highlighting the Global Benefit of Translational Research

by Francoise Barre-Sinoussi
HIV, a Discovery Highlighting the Global Benefit of Translational Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1498 views
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The fantastic progress made in medicine led the scientific community to hope about the complete eradication of infectious diseases in the middle of the 20th century. The sudden emergence of AIDS in the early 80's cruelly reminded us that this dream ....

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