73 results found for biochemistry

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00:29:00

The Killer Defence

by Peter Doherty
The Killer Defence
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1460 views
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Immune surveillance by virus-specific CD8+ cytotoxic T lymphocytes (CTLs), or killer T cells, has long been known to be central to the control of acute infections and some cancers, though the role of CTL memory in the rapid recall of immune protectio....

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00:39:00

Role of Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development

by Ferid Murad
Role of Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1778 views
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Nitric oxide research has grown rapidly with about 150,000 research publications describing its biological effects. It is an important messenger molecule that affects most tissues and biological processes. Many effects of nitric oxide are mediated by....

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00:30:00

Ion Channels: Their Discovery, their Function and their Role in Diseases

by Erwin Neher
Ion Channels: Their Discovery, their Function and their Role in Diseases
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1559 views
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The concept of bioelectricity emerged in the late 18th century, based on the experiments of Galvani and Volta. Sixty years ago, Hodgkin and Huxley showed that the nerve impulse is a result of permeability changes of the nerve membrane. This raised th....

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00:30:00

The Origin of Reversible Protein Phosphorylation as a Regulatory Mechanism

by Edmond Fischer
The Origin of Reversible Protein Phosphorylation as a Regulatory Mechanism
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1658 views
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Reversible protein phosphorylation can be considered one of the most prevalent mechanism by which eukaryotic cellular events are regulated. It is directly involved in numerous pathological conditions, and bacterial and viral diseases. This process wa....

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00:27:00

Roles of the Ubiquitin System in Health and Disease

by Avram Hershko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1299 views
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The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....

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00:31:00

Structural Aspects of Protease Control in Health and Disease

by Robert Huber
Structural Aspects of Protease Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1297 views
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This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....

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00:32:00

Aquaporin Water Channels – From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels – From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 2920 views
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Aquaporin channels allow water to rapidly cross cell membranes in all living organisms. AQP1 confers red cells and proximal renal tubules with high water permeability. Present in renal collecting duct, AQP2 is regulated by vasopressin, and human muta....

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00:32:00

Bioinspired genotype–phenotype linkages

by Florian Hollfelder
Bioinspired genotype–phenotype linkages
for 14-19 and upwards,
Lectures | 14-19 and upwards | 8 years ago | 1461 views
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Florian Hollfelder is based in the Department of Biochemistry at the University of Cambridge. He is interested in mechanism in chemistry and biology. Here he describes using principles of natural selection to make functional proteins.

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01:10:00

Bacterial cell walls, antibiotics and the origins of life

by Jeff Errington
Bacterial cell walls, antibiotics and the origins of life
for 14-19 and upwards,
Lectures | 14-19 and upwards | 8 years ago | 1247 views
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The cell wall is a crucial structure found in almost all bacteria. It is the target for our best antibiotics and fragments of the wall trigger powerful innate immune responses against infection. Surprisingly, many bacteria can switch almost effortl....

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00:32:00

Tickling Worms: Surprises From Basic Research

by Martin Chalfie
Tickling Worms: Surprises From Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1268 views
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Research, at least my research, has never been linear. I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and peoples interests. This lack of direction....

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00:42:00

Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development

by Ferid Murad
Discovery of Nitric Oxide and Cyclic GMP in Cell Signaling and Their Role in Drug Development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 2373 views
Rating:

The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....

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00:33:00

Structural Biology and its Translation into Practice and Business: My Experience

by Robert Huber
Structural Biology and its Translation into Practice and Business: My Experience
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1588 views
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As a student in the early 1960s, I had the privilege to attend winter seminars organized by my mentor, W. Hoppe, and by M. Perutz, which took place in a small guesthouse in the Bavarian-Austrian Alps. The entire community of a handful of protein cry....

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