Minimizing a Bacterial Genome by Global Design and Synthesis
In 2010, we chemically synthesized the 1078 Kb Mycoplasma mycoides genome and transplanted it into a recipient cell cytoplasm to create a 'synthetic cell', JCVI-syn1.0 (Science, 329, 52-56, 2010). We identified several hundred non-essential genes by ....
More details | Watch nowRole of Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development
Nitric oxide research has grown rapidly with about 150,000 research publications describing its biological effects. It is an important messenger molecule that affects most tissues and biological processes. Many effects of nitric oxide are mediated by....
More details | Watch nowThe Adventure of Cold Atoms. From Optical Pumping to Quantum Gases
Conservation laws are very important in quantum physics. Two examples of applications will be given. First, optical pumping which uses transfer of angular momentum from polarized photons to atoms to produce highly polarized atomic gases. Then, laser ....
More details | Watch nowWhat About Redefining Time Using a Stable Laser?
Several laser-based Atomic Clocks now have an accuracy potential of ~2 x10-18, a hundred-fold better than the best achieved after more than 60 years' experience with rf resonances in Cs atoms. Still, this long attention span documents that the Cs Fou....
More details | Watch nowWhere am I From? Where Are You Going?
Scientific research is a never-ending 'journey of knowledge'. There is more meaning in experiencing various encounters and making a good journey itself than reaching the destination. Basic science has eternal cultural value; it has served to heighten....
More details | Watch nowOn the Genetic Basis of Morphological Evolution
Darwin's theory of evolution states that variation of the shape and pattern of the adults rather than the embryos are the basis for natural selection. In order to understand how morphological variation arises, it is important to identify the genes th....
More details | Watch nowFrom the Structure of the Ribosome to the Design of New Antibiotics
Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanism of action of a ....
More details | Watch nowProtein Cross Talk in Cell Signaling
The main focus of the talk will be on signaling by tyrosine phosphorylation, which has been directly implicated in the regulation of cell growth, differentiation and transformation. External signals coming in the form of mitogenic hormones and growt....
More details | Watch nowTelomeres and Telomerase in Human Health and Disease
Telomeres are the protective tips that stabilize the ends of chromosomes. The function of telomeres is to allow cells to divide while holding the genetic material intact. Telomeres contain specialized, simple repetitive DNA sequences that, together....
More details | Watch nowWhich Way For Physics?
This talk describes a new approach to the problem of characterising physical reality, one with the potential to fill in gaps in the conventional understanding of nature. It is based on a different view from the usual one of structure at the finest l....
More details | Watch nowGenerating the Fuel of Life
The lecture will be devoted to the topic of how the biological world supplies itself with energy to make biology work, and what medical consequences ensue when the energy supply chain in our bodies is damaged or defective. We derive our energy from ....
More details | Watch nowShort-term Synaptic Plasticity
Our brain is a network of about 10^11 neurons, which are connected via synapses. A neuron typically receives input from about 10000 other neurons, which can be either excitatory or inhibitory. The neuron integrates these inputs and generates an actio....
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