The Discovery of Helicobacter
Before the 1970s, well fixed specimens of gastric mucosa were rare. Then the flexible endoscope was introduced. This enabled gastroenterologists to take numerous well-fixed small biopsies from the stomach. Gastric histology and pathology were clearly....
More details | Watch nowAre We Going to Cure all Diseases and at What Price?
We are exiting the era where our approach to treatment of these and many other diseases is 'one size fits all', and enter a new era of 'personalized medicine' where we shall tailor the treatment according to the patient's molecular/mutational profile....
More details | Watch now2014 3MT Competition Finals: Resistance Training & Protein Supplementation on Body Composition in Breast Cancer Survivors
HIV, a Discovery Highlighting the Global Benefit of Translational Research
The fantastic progress made in medicine led the scientific community to hope about the complete eradication of infectious diseases in the middle of the 20th century. The sudden emergence of AIDS in the early 80's cruelly reminded us that this dream ....
More details | Watch nowProgrammed Cell Death in Development and Disease
Programmed cell death (often referred to as apoptosis) is a normal feature of animal development and tissue homeostasis. The misregulation of cell death has been implicated in a diversity of human disorders, including cancer, autoimmune diseases, he....
More details | Watch nowNatural Selection and the Future of Life
In his lecture Professor Christian Rene de DuvŽ gives a rough overview on the history of life starting about 3.5 billion years ago with the first cells up to the appearance of the first primates 70 million years ago, and he states that all organisms....
More details | Watch nowOn the Genetic Basis of Morphological Evolution
Darwin's theory of evolution states that variation of the shape and pattern of the adults rather than the embryos are the basis for natural selection. In order to understand how morphological variation arises, it is important to identify the genes th....
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The association of DNA with water is known since the deciphering of its double helical structure by X-Ray diffraction in 1953 (Watson, Crick, Wilkins and Franklin). However the power of DNA for organizing water seems to go far beyond the direct fill....
More details | Watch nowCultural Values of Scientific Knowledge
The acquisition of scientific knowledge largely depends on the availability of appropriate research approaches and methodologies. Novel scientific knowledge represents cultural values. On the one hand, it enriches our world-view with impacts on our....
More details | Watch nowThe Future of Life
Ever since its first appearance, more than 3.5 billion years ago, life has evolved without guiding plan, propelled by: 1) its own intrinsic properties, which, with the help of outside energy, provided the necessary driving force; 2) accidental geneti....
More details | Watch nowFrom the Structure of the Ribosome to the Design of New Antibiotics
Structural studies of the ribosome exemplify the evolution of structural studies in cell biology from the early negatively stained images of macromolecular assemblies in whole cells, to a detailed atomic understanding of the mechanism of action of a ....
More details | Watch nowDiscovery of Nitric Oxide and Cyclic GMP in Cell Signalling and their Role in Drug Development
The role of nitric oxide in cellular signaling in the past three decades has become one of the most rapidly growing areas in biology. Nitric oxide is a gas and a free radical with an unshared electron that can regulate an ever-growing list of biolog....
More details | Watch nowThe Lability of the Differentiated State
Many classical studies have shown that cell fates become progressively restricted during development and that this restriction is typically irreversible. This has led to the dogma of the Stability of the Differentiated State: cells cannot typically ....
More details | Watch nowUpdated Notions on Darwinian Evolution
Charles Darwin had based his theory of biological evolution on the observation that phenotypic variants of a given species can sometimes over-grow their parental population, and he attributed this to selective advantage, i.e., to the impact of natura....
More details | Watch nowProtein Cross Talk in Cell Signaling
The main focus of the talk will be on signaling by tyrosine phosphorylation, which has been directly implicated in the regulation of cell growth, differentiation and transformation. External signals coming in the form of mitogenic hormones and growt....
More details | Watch nowSignals and Signalling Mechanisms in the Central Nervous System
Our brain is a network of about 10^11 neurons, which are connected by synapses. A neuron typically receives input from about 10000 other neurons, which can be either excitatory or inhibitory. The neuron integrates these inputs and generates an 'act....
More details | Watch nowInfections in the Etiology of Human Cancers
During the past century a number of chemical and physical risk factors for human cancers have been identified. Only relatively recently, mainly during the past 30 years, infectious agents have been identified as important human carcinogens. Besides....
More details | Watch nowClimbing the Everest Beyond the Everest
The challenges associated with pursuing ribosomal crystallography can be described as a series of Everest climbing. At each step, when reaching the summit, a taller and more difficult one became exposed. Snapshots of this story will be described.__....
More details | Watch nowTelomeres and Telomerase in Human Health and Disease
Telomeres are the protective tips that stabilize the ends of chromosomes. The function of telomeres is to allow cells to divide while holding the genetic material intact. Telomeres contain specialized, simple repetitive DNA sequences that, together....
More details | Watch nowSimulation of cell seeding and cell mechanical forces in tissue engineering
A brief description of the factors which are involved in simulating various effects in tissue engineering research.
More details | Watch nowBiofunctionalized magnetic nanoparticles for tumor therapy
Baiju describes the important uses of magnetic nano particles for delivering anti-cancer drugs. This talk was part of his PhD thesis defence.
More details | Watch nowBiocompatible Nanoparticles: A nanoplatform for imaging and drug delivery to cancer cells
Aswathy presents her PhD thesis defence lecture where she describes the use in drug-delivery of nanoparticles.
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