92 results found for biology

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00:35:00

Telomeres: Telling Tails

by Elizabeth Blackburn
Telomeres: Telling Tails
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1850 views
Rating:

Telomeres protect chromosome ends and help stabilize the genome. Throughout human life and in aging, telomeres often erode down, eventually causing cells to malfunction or die. The highly regulated cellular enzyme telomerase adds telomeric DNA to tel....

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00:29:00

The Killer Defence

by Peter Doherty
The Killer Defence
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1461 views
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Immune surveillance by virus-specific CD8+ cytotoxic T lymphocytes (CTLs), or killer T cells, has long been known to be central to the control of acute infections and some cancers, though the role of CTL memory in the rapid recall of immune protectio....

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00:31:00

Minimizing a Bacterial Genome by Global Design and Synthesis

by Hamilton Smith
Minimizing a Bacterial Genome by Global Design and Synthesis
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 2139 views
Rating:

In 2010, we chemically synthesized the 1078 Kb Mycoplasma mycoides genome and transplanted it into a recipient cell cytoplasm to create a 'synthetic cell', JCVI-syn1.0 (Science, 329, 52-56, 2010). We identified several hundred non-essential genes by ....

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00:39:00

Role of Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development

by Ferid Murad
Role of Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1778 views
Rating:

Nitric oxide research has grown rapidly with about 150,000 research publications describing its biological effects. It is an important messenger molecule that affects most tissues and biological processes. Many effects of nitric oxide are mediated by....

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00:30:00

Ion Channels: Their Discovery, their Function and their Role in Diseases

by Erwin Neher
Ion Channels: Their Discovery, their Function and their Role in Diseases
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1559 views
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The concept of bioelectricity emerged in the late 18th century, based on the experiments of Galvani and Volta. Sixty years ago, Hodgkin and Huxley showed that the nerve impulse is a result of permeability changes of the nerve membrane. This raised th....

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00:31:00

The Origins of Cellular Life

by Jack Szostak
The Origins of Cellular Life
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1612 views
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The complexity of modern biological life has long made it difficult to understand how life could emerge spontaneously from the chemistry of the early earth. We are attempting to synthesize simple artificial cells in order to discover plausible pathwa....

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00:30:00

The Origin of Reversible Protein Phosphorylation as a Regulatory Mechanism

by Edmond Fischer
The Origin of Reversible Protein Phosphorylation as a Regulatory Mechanism
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1658 views
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Reversible protein phosphorylation can be considered one of the most prevalent mechanism by which eukaryotic cellular events are regulated. It is directly involved in numerous pathological conditions, and bacterial and viral diseases. This process wa....

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00:27:00

A Crime against Humanity

by Richard Roberts
A Crime against Humanity
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1707 views
Rating:

When Monsanto first tried to introduce GMO seeds into Europe there was a backlash by the Green parties and their political allies, who feared that American agro-business was about to take over their food supply. Thus began a massive campaign not agai....

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00:31:00

Finding Mutations that Affect Immunity

by Bruce Beutler
Finding Mutations that Affect Immunity
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1606 views
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Beginning with an exception to normal function caused by a genetic aberration, one may hope to find at least one protein with non-redundant function in a certain biological process. This approach permitted the identification of the receptor for bacte....

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00:34:00

Insight into the Laws of Nature for Biological Evolution

by Werner Arber
Insight into the Laws of Nature for Biological Evolution
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1708 views
Rating:

Both evolutionary biology and genetics have their roots 150 years ago in work with phenotypic variants of plants and animals. In contrast, microbial genetics originating as recently as the 1940s, rapidly revealed that filamentous DNA molecules are th....

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00:29:00

From Proto-oncogenes to Precision Oncology

by Harold Varmus
From Proto-oncogenes to Precision Oncology
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1815 views
Rating:

The diagnosis, classification, and treatment of human cancers are being transformed by scientific discoveries that were strongly influenced by the discovery of the c-src proto-oncogene, as described in the lecture by Michael Bishop. The path to this ....

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00:32:00

Tickling Worms – Surprises from Basic Research

by Martin Chalfie
Tickling Worms – Surprises from Basic Research
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1350 views
Rating:

Research, at least my research, has never been linear. I have found that my lab and I often double back on problems after years of inactivity or go off in entirely new directions as dictated by the work and people's interests This lack of direction r....

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00:29:00

How to Model the Action of Complex Biological Systems on a Molecular Level

by Arieh Warshel
How to Model the Action of Complex Biological Systems on a Molecular Level
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 2103 views
Rating:

Despite the enormous advances in structural studies of biological systems we are frequently left without a clear structure function correlation and cannot fully describe how different systems actually work. This introduces a major challenge for compu....

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00:25:00

Physical perspective on cytoplasmic streaming

by Ray Goldstein
Physical perspective on cytoplasmic streaming
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1282 views
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Professor Ray Goldstein FRS is the Schlumberger Professor of Complex Physical Systems at the University of Cambridge. Here he describes a biological example of topological inversion, with relevance to engineering problems in human technology.

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00:03:00

2014 3MT Competition Finals: Resistance Training & Protein Supplementation on Body Composition in Breast Cancer Survivors

by Takudzwa Madzima
2014 3MT Competition Finals: Resistance Training & Protein Supplementation on Body Composition in Breast Cancer Survivors
for 18-22 and upwards22 and upwards,
Postgraduate presentations | 18-22 and upwards22 and upwards | 9 years ago | 1948 views
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00:03:00

2014 3MT Competition Finals: Histone Variant H3.3 is Required for DNA Repair

by Sarah Burkhart
2014 3MT Competition Finals: Histone Variant H3.3 is Required for DNA Repair
for 18-22 and upwards22 and upwards,
Postgraduate presentations | 18-22 and upwards22 and upwards | 9 years ago | 4498 views
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00:03:00

2014 3MT Competition Finals: A Behavioral and Molecular Examination of “Umami” Taste

by Kimberly Smith
2014 3MT Competition Finals: A Behavioral and Molecular Examination of “Umami” Taste
for 18-22 and upwards22 and upwards,
Postgraduate presentations | 18-22 and upwards22 and upwards | 9 years ago | 12093 views
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00:37:00

Generating the Fuel of Life

by John Walker
Generating the Fuel of Life
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1372 views
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The lecture will be devoted to the topic of how the biological world supplies itself with energy to make biology work, and what medical consequences ensue when the energy supply chain in our bodies is damaged or defective. We derive our energy from ....

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00:31:00

Biological Evolution in the Context of Cosmic Evolution and of Cultural Evolution

by Werner Arber
Biological Evolution in the Context of Cosmic Evolution and of Cultural Evolution
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1589 views
Rating:

After reconsidering the very long time periods in cosmic evolution, we will focus our attention to the evolutionary development of living organisms on our planet Earth. The genetic variants (mutations), which are occasionally produced, are alteratio....

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00:33:00

Structural Biology and its Translation into Practice and Business: My Experience

by Robert Huber
Structural Biology and its Translation into Practice and Business: My Experience
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1588 views
Rating:

As a student in the early 1960s, I had the privilege to attend winter seminars organized by my mentor, W. Hoppe, and by M. Perutz, which took place in a small guesthouse in the Bavarian-Austrian Alps. The entire community of a handful of protein cry....

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00:36:00

A Personal View of the History of Nuclear Magnetic Resonance in Biology and Medicine

by Kurt Wurthrich
A Personal View of the History of Nuclear Magnetic Resonance in Biology and Medicine
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1755 views
Rating:

In 1952, Felix Bloch and Edward Purcell were awarded the Nobel Prize in Physics for the description of the phenomenon of nuclear magnetic resonance (NMR). Over the years, NMR has been used in a wide range of fundamental studies in physics, and in the....

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00:34:00

Synthetic Biology for Genetic Engineering in the 21st Century

by Hamilton Smith
Synthetic Biology for Genetic Engineering in the 21st Century
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1350 views
Rating:

Synthetic biologists seek to design, build, and test novel biological systems. We have chemically synthesized a bacterial genome (Mycoplsama mycoides, 1078Kb) and brought it to life by transplantation into the cytoplasm of a related species. We are....

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00:32:00

The Revolution of Personalized Medicine: Are We Going to Cure All Diseases and at What Price?

by Aaron Ciechanover
The Revolution of Personalized Medicine: Are We Going to Cure All Diseases and at What Price?
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1467 views
Rating:

Many important drugs such as penicillin, aspirin, or digitalis, were discovered by serendipity - some by curious researchers who accidentally noted a "strange" phenomenon, and some by isolation of active ingredients form plants known for centuries to....

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00:31:00

Multiscale Simulations of the Functions of Biological Molecules

by Arieh Warshel
Multiscale Simulations of the Functions of Biological Molecules
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 2772 views
Rating:

Despite enormous advances in structural studies of biological systems we are frequently left without a clear structure-function correlation and cannot fully describe how different systems actually work. This introduces a major challenge for computer....

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