Roles of the Ubiquitin System in Health and Disease
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....
More details | Watch nowStructural Aspects of Protease Control in Health and Disease
This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....
More details | Watch nowAquaporin Water Channels – From Atomic Structure to Malaria
Aquaporin channels allow water to rapidly cross cell membranes in all living organisms. AQP1 confers red cells and proximal renal tubules with high water permeability. Present in renal collecting duct, AQP2 is regulated by vasopressin, and human muta....
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