G Protein Coupled Receptors: Challenges for Drug Discovery

View G Protein Coupled Receptors: Challenges for Drug Discovery

Presenter: Brian Kobilka

Published: July 2014

Age: 18-22 and upwards

Views: 1436 views

Tags: Protein;coupled;receptors;gpcr;gpcrs;

Type: Lectures

Source/institution: Lindau-Nobel


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G protein coupled receptors (GPCRs) conduct the majority of cellular responses to hormones and neurotransmitters, and are therefore the largest group of pharmaceutical targets for a broad spectrum of diseases.  Identification of genes for GPCRs, initially through cloning and subsequently through database mining, raised hopes for the rapid discovery of new therapeutics. However, the number of new approved drugs for GPCR targets over the past two decades has fallen short of expectations. Dr Kobilka discusses challenges in GPCR drug discovery and the potential impact of structural biology and other scientific advances on future drug discovery efforts.