Engineering Molecules for Fun, Profit, and Clinical Relevance
Presenter: Roger Tsien
Published: July 2014
Age: 18-22 and upwards
Views: 1142 views
Tags: fluorescence; photomultiplier;calcium
Type: Lectures
Source/institution: Lindau-Nobel
Watch now
Molecules to observe and manipulate biological systems and disease processes can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures will be chosen from my own experience, including calcium indicators, molecular voltmeters and photomultipliers, fluorescent proteins, and peptides that light up tumors and nerves. The key personal challenge is to match one’s own neuroses and pleasures with research challenges that will have the widest possible impact.