Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms

View Building and Breeding Molecules to Spy on Cells, Tumors, and Organisms Building - L-N - Tsien - Chem 2009

Presenter: Roger Tsien

Published: July 2014

Age: 18-22 and upwards

Views: 753 views

Tags: biochemistry;synthesis;genome

Type: Lectures

Source/institution: Lindau-Nobel

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Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures will be chosen mainly from my own experience, including calcium and sodium indicators, caged second messengers, molecular voltmeters and photomultipliers, fluorescent proteins, genetically encoded indicators of intracellular biochemistry, and clinically applicable peptides to target human tumors.

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