Adventures in Nontranslational Research
Professor Martin Chalfie regrets the disproportionately high funding of translational research, defined as applied research for the treatment of human diseases. With examples from the research in his lab he wants to show how important nontranslatio....
More details | Watch nowAquaporin Water Channels _ From Atomic Structure to Malaria
Aquaporin (AQP) water channel proteins enable high water permeability in certain biological membranes. Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known. Expres....
More details | Watch nowAquaporin Water Channels: From Atomic Structure to Malaria
Aquaporin (AQP) water channel proteins enable high water permeability of certain biological membranes. Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known. Expr....
More details | Watch nowBasic Science and Co-entrepreneurship, my Experience
The design and development of inhibiting (or occasionally activating) ligands of target proteins in medicine and crop protection guided by molecular structures and functions has become an established technology in academia and industry recently._ Dr....
More details | Watch nowBioinspired genotype–phenotype linkages
Florian Hollfelder is based in the Department of Biochemistry at the University of Cambridge. He is interested in mechanism in chemistry and biology. Here he describes using principles of natural selection to make functional proteins.
More details | Watch nowBreaking down Altzheimer’s
Alzheimer's disease is caused by abnormal clumps or aggregations of proteins in the brain. Simon P”psel is about to embark on PhD work on a protein that might help us to treat this devastating disease, and Nobel Prize winning biochemist Aaron Ciech....
More details | Watch nowBreast Cancer Susceptibility Gene BRCA2
BRAC2 is a tumor suppressor gene. Its protein product interacts with other proteins to assist regulation of DNA repair, transcription and cell cycle checkpoints. BRAC2 gene disruption may lead to protein truncation, mutations and loss of function. Ce....
More details | Watch nowBuilding and Breeding Molecules to Spy on Cells, Tumors, and Organisms
Molecules to observe and manipulate biological systems can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures ....
More details | Watch nowClimbing the Everest Beyond the Everest
The challenges associated with pursuing ribosomal crystallography can be described as a series of Everest climbing. At each step, when reaching the summit, a taller and more difficult one became exposed. Snapshots of this story will be described.__....
More details | Watch nowConformational Plasticity of G-Protein-Coupled Receptors (GPCRs) studied by NMR in Solution
As an introduction, some principles of nuclear spin physics applying to studies of integral membrane proteins (IMP) will be reviewed. Applications of resulting nuclear magnetic resonance (NMR) techniques will then be illustrated with studies of G-p....
More details | Watch nowCuriosity and its Fruits: From Basic Science to Advanced Medicine
Ribosomes, the universal cellular machines that translate the genetic code into proteins, are targeted by many antibiotics that paralyze them by binding to their functional sites. Antibiotics binding modes, inhibitory actions and synergism pathways....
More details | Watch nowEngineered zinc finger proteins and gene expression
It has long been the goal of molecular biologists to design DNA binding proteins for the specific control of gene expression. The zinc finger design, discovered by Sir Aaron Klug 20 years ago, is ideally suited for such purposes, discriminating betwe....
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