45 results found for proteins

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00:30:00

Ion Channels: Their Discovery, their Function and their Role in Diseases

by Erwin Neher
Ion Channels: Their Discovery, their Function and their Role in Diseases
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1559 views
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The concept of bioelectricity emerged in the late 18th century, based on the experiments of Galvani and Volta. Sixty years ago, Hodgkin and Huxley showed that the nerve impulse is a result of permeability changes of the nerve membrane. This raised th....

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00:29:00

From Proto-oncogenes to Precision Oncology

by Harold Varmus
From Proto-oncogenes to Precision Oncology
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1814 views
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The diagnosis, classification, and treatment of human cancers are being transformed by scientific discoveries that were strongly influenced by the discovery of the c-src proto-oncogene, as described in the lecture by Michael Bishop. The path to this ....

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00:27:00

Roles of the Ubiquitin System in Health and Disease

by Avram Hershko
Roles of the Ubiquitin System in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1299 views
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The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small....

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00:31:00

Structural Aspects of Protease Control in Health and Disease

by Robert Huber
Structural Aspects of Protease Control in Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 8 years ago | 1297 views
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This lecture starts out with a very brief review of the history of protein crystallography and continue with our studies since 1970 on proteolytic enzymes and their control. Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic....

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00:32:00

Bioinspired genotype–phenotype linkages

by Florian Hollfelder
Bioinspired genotype–phenotype linkages
for 14-19 and upwards,
Lectures | 14-19 and upwards | 8 years ago | 1461 views
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Florian Hollfelder is based in the Department of Biochemistry at the University of Cambridge. He is interested in mechanism in chemistry and biology. Here he describes using principles of natural selection to make functional proteins.

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01:01:00

Genetic control and the mammalian radiation

by Duncan Odom
Genetic control and the mammalian radiation
for 14-19 and upwards,
Lectures | 14-19 and upwards | 9 years ago | 1112 views
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To grow tissues in our body two key types of DNA control how, where and when to build essential proteins. Recent comparisons of mammal genomes show that instructions coding how to build proteins are similar across diverse species. In contrast the gen....

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00:29:00

Protein Cross Talk in Cell Signaling

by Edmond Fischer
Protein Cross Talk in Cell Signaling
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1319 views
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The main focus of the talk will be on signaling by tyrosine phosphorylation, which has been directly implicated in the regulation of cell growth, differentiation and transformation. External signals coming in the form of mitogenic hormones and growt....

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00:41:00

Climbing the Everest Beyond the Everest

by Ada Yonath
Climbing the Everest Beyond the Everest
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1724 views
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The challenges associated with pursuing ribosomal crystallography can be described as a series of Everest climbing. At each step, when reaching the summit, a taller and more difficult one became exposed. Snapshots of this story will be described.__....

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00:41:00

Telomeres and Telomerase in Human Health and Disease

by Elizabeth Blackburn
Telomeres and Telomerase in Human Health and Disease
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 2848 views
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Telomeres are the protective tips that stabilize the ends of chromosomes. The function of telomeres is to allow cells to divide while holding the genetic material intact. Telomeres contain specialized, simple repetitive DNA sequences that, together....

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00:29:00

Membrane Proteins: Importance, Functions, Mechanisms

by Hartmut Michel
Membrane Proteins: Importance, Functions, Mechanisms
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 1408 views
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Biological membranes define and compartmentalize the cells of higher organisms. Consisting of membrane proteins and lipids, they are basically impermeable for ions and polar substances, so that electric voltages (_membrane potentialsî) and substanc....

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00:32:00

Aquaporin Water Channels _ From Atomic Structure to Malaria

by Peter Agre
Aquaporin Water Channels _ From Atomic Structure to Malaria
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 3451 views
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Aquaporin (AQP) water channel proteins enable high water permeability in certain biological membranes. Discovered in human red cells but expressed in multiple tissues, AQP1 has been thoroughly characterized and its atomic structure is known. Expres....

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00:31:00

Genes and Proteins that Control Secretion and Autophagy

by Randy Schekman
Genes and Proteins that Control Secretion and Autophagy
for 18-22 and upwards,
Lectures | 18-22 and upwards | 9 years ago | 3349 views
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The broad outlines of the secretory pathway were established by pioneering EM and cell fractionation experiments conducted by George Palade in the 1960s. Beginning in the mid 1970s and early 80s, my laboratory isolated a series of conditionally leth....

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